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KMID : 0364519930040020203
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Dong-A Journal Medicine
1993 Volume.4 No. 2 p.203 ~ p.210
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Study on the Effect of Tranquilizing Doses of Lorazepam on Reigonal Cerebral Blood Flow
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한홍무
양창국/양승오
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Abstract
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Regional cerebral blood flow(rCBF) is closely coupled with brain function, drug-induced changes in the latter are accompanied by parallel changes in the former. Thus, rCBF study is generally believed to hold much promise for the future in
psychiatric
research.
Benzodiazepines like lorazepam is the one of the most widely prescribed psychotropic drugs in psychiatric fields and induce tranquilization in small doses and sedation in larger quantities.
We performed this study to investigate the effects of tranquilizing doses of lorazepam on rCBF and their clinical significances. RCBF was measured with SPECT using 99mTc-HMPAO before and 40 minutes after slow intravenous administration of
0.02mg/kg
body
weight of lorazepam(Mean±SD=1.33±0.06mg) or normal saline given on a double-blind basis to 20 right-nanded normal male volunteers.
Subjects who received lorazepam showed significant both hemispheric rCBF decrease, more in the right hemisphere, but there were no significant differences between regions of interest, Whereas controls did not show significant differences between
the two
sets of values. None of the subjects became sleepy during the experiment.
The above findings suggest that mood changes induced by tranquilizing doses of lorazepam might be mediated through the supression of the brain function, especially the nondominant hemisphere.
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KEYWORD
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